DHT and acne

[dime]

Is it possible that there's a correlation with 5-alpha-reductase activity in the skin and formation of acne?

A study suggests that there's significantly more 5-AR (type 1) activity in sebaceous glands in acne-prone skin, than in non-acne skin (Thiboutot et al.).
More 5-AR activity translates to more DHT production -> more inflammation (as we know from many studies on hair loss) -> acne in acne-prone people (same like hair loss in certain people)?

[RRM]

Yes. In some acne patients the level of DHT is higher, whereas in others the receptors are more responsive to the influence of DHT,
whereas in others its testosterone, or progesterone, and/or their receptors.